Day 1 :
The Chinese University of Hong Kong, China
Time : 09:00 AM
Professor WK Tang was appointed to professor in the Department of Psychiatry, the Chinese University of Hong Kong in 2011. His main research areas are Addictions and Neuropsychiatry in Stroke. Professor Tang has published over 100 papers in renowned journals, and has also contributed to the peer review of 40 journals. He has secured over 20 major competitive research grants. He has served the editorial boards of five scientific journals. He was also a recipient of the Young Researcher Award in 2007, awarded by the Chinese University of Hong Kong.
Depression is common following an acute stroke. Poststroke Depression (PSD) have notable impacts on the function recovery and quality of life of stroke survivors. Incidence decreased across time after stroke, but prevalence of PSD tend to be stable. Many studies have explored the association between lesion location and the incidence of PSD. For example, lesions in frontal lobe, basal ganglia and deep white matter have been related with PSD. Furthermore, cerebral microbleeds and functional changes in brain networks have also been implicated in the development of PSD. In this presentation, evidences of such association between the above structural and functional brain changes and PSD will be reviewed.Acknowledgement:This project is supported by the following grants.Health and Medical Research Fund, reference number: 02130726 Health and Medical Research Fund, reference number: 01120376 National Natural Science Foundation of China, reference number: 81371460General Research Fund, reference number: 474513General Research Fund, reference number: 473712
Professor and Vice-Chair, Stanford University
Dr. Carrion is the John A. Turner, M.D. Endowed Professor and Vice-Chair in the Department of Psychiatry and Behavioral Sciences at Stanford University and Director of the Stanford Early Life Stress and Pediatric Anxiety Program. He is in the faculty at both Stanford University School of Medicine and Lucile Packard Children’s Hospital. His multidisciplinary research on the behavioral, academic, emotional, and biological late effects of experiencing trauma has led to the development and implementation of effective new interventions for treating children who experience traumatic stress. Using Posttraumatic Stress Disorder (PTSD) as an anchor, Dr. Carrion is investigating, through longitudinal studies, the effects of stress on developmental physiology and brain development and function.
Statement of the Problem: 35% of youth living in communities of high violence will develop significant posttraumatic stress disorder symptoms. Current treatment modalities that anchor in cognitive behavioral therapy (CBT) may leave 20-50% of youth without adequate symptom relieve. New treatment modalities that address executive function, memory and emotion regulation are needed, and access and dissemination should be taken into consideration. This presentation will introduce Stanford’s Cue-Centered Therapy (CCT) and a school-district wide prevention effort that involves yoga and mindfulness in students’ curriculum. CCT integrates elements from CBT with other empirically validated interventions for traumatized youth (psychodynamic therapy, insight, self-efficacy, education). The prevention study focuses on health and wellness through meditation and exercise. Methodology & Theoretical Orientation: Our research identifying key brain regions (e.g.; hippocampus, amygdala, prefrontal cortex) alterations in structure and function as related to traumatic stress informed the development of CCT. CCT demonstrated effectiveness in reducing anxiety, depression and posttraumatic stress symptoms in a randomized controlled trial. We are currently engaged in treatment outcome research to demonstrate CCT’s efficacy in improving brain function and cognitive and emotional outcomes. Findings: The presentation will focus on our imaging (sMRI and fMRI) and salivary cortisol studies that set the stage for the development of CCT. In addition, sleep was investigated in our prevention study. A curriculum of yoga and mindfulness improves sleep variables and these will be presented. Conclusion & Significance: New treatment modalities and dissemination plans need to be developed to address the highly heterogenous group of children that fall under the diagnostic umbrella of posttraumatic stress disorder (PTSD). Approaching both prevention and treatment that are informed by neuroscience research promises to make our interventions more focused and targeted.