Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 30th International Conference on Psychiatry and Mental Health Tokyo, Japan.

Day 1 :

Keynote Forum

Nigila Ravichandran

Adjunct Assistant Professor & Consultant Institute of Mental Health, Singapore

Keynote: Does Educational Level Influence Sustained Employment in Patients with Schizophrenia?

Time : 11:00-11:45

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Nigila Ravichandran  photo
Biography:

Dr Nigila Ravichandran MBBS (India), Master of Medicine (Psychiatry) (NUS Singapore), Dip Hypnotherapy (LCCH) Adjunct Assistant Professor, Lee Kong Chian School of Medicine (Singapore) Senior Lecturer, Yong Loo Lin School of Medicine (Singapore) Consultant, Psychiatrist, Institute of Mental Health (Singapore) 17 years of experience working in the field of mental health, in areas of clinical psychiatry, academic teaching and research Passion for community causes, speaker at Community events and forums, television and health fairs on mental wellness and mental health conditions Board member of Club2Care, charity organization, geared towards creating awareness about mental health, training and counselling community partners and building a mentally healthy society

Abstract:

Background

Schizophrenia is a chronic mental illness causing significant socio-occupational impairment. Although occupational opportunities usually correspond with educational qualifications, research shows that several factors influence employment among mentally ill (1). Higher education correlates with better outcome with rehabilitative measures like cognitive training (2).

An observational study was conducted at the Institute of Mental Health (IMH), the tertiary mental healthcare and rehabilitation centre at Singapore, to identify major variables associated with employment among patients with Schizophrenia.

In Singapore, all residents receive at least primary level education.

Objectives

To explore whether educational status determines employability and job sustainability in persons with schizophrenia.

Methods

Residents of Singapore with DSM-IV diagnosis of Schizophrenia attending IMH clinics were included for study. Relevant data was collected from 120 consenting participants.

Results

Of the 120 participants, 49.2% had attained secondary education and 18.3% employed; 31.7% had university education and 15% were employed. In total, 38.3% were working at time of study and 60.8% in the past.

87.5% (43% secondary and 30% university educated respectively) participants had rehabilitation potential as expressed by self-interest and past employment.

Conclusions

Educational level only facilitates initial job-seeking and does not ensure long-term employment; but it improves potential for rehabilitation, which in turn enhances job sustainability in mentally unwell persons.

 

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Lyzwinski Lynnette Nathalie photo
Biography:

Lynnette Lyzwinski is completed her PhD in Medicine at the school of Medicine at UQ in the Department of Psychiatry and the Centre for Online Health. Her research interests include clinical trials and health promotions behaviors for promoting mental wellbeing and reducing lifestyle behavioral risk factors. She has special interests in mHealth, mindfulness, and lifestyle medicine.

 

Abstract:

Background: University students are at risk of weight gain during their studies. Key factors related to weight gain in this population include unhealthy weight related behaviors due to stress. Mindfulness holds promise for weight management. However, there has not been a previous trial that has explored the effectiveness of a student-tailored mindfulness app for stress, weight related behavior’s and weight. There is limited evidence that current mindfulness apps use evidence-based mindfulness techniques. A novel app was developed that combined evidence-based mindfulness-based stress reduction and mindful eating techniques that were tailored to university students, with student relevant themes for targeting weight behavior’s, weigh and stress.

Method: A two arm Randomized Controlled Trial (RCT) of 11 weeks duration was undertaken at the University of Queensland. Students were randomized to the mindfulness app (N=45) or to a behavioral self-monitoring electronic diary (e-diary) (N=45) for diet and exercise. Analysis of covariance was used to compare differences in weight, stress, mindfulness, mindful eating, physical activity and eating behaviors between both groups.

Results: Neither the mindfulness app group nor the e-diary group lost weight nor there were no differences between groups at follow-up. The mindfulness app group had significantly lower stress levels (adherers only), lower emotional eating and uncontrolled eating as well as higher mindfulness and mindful eating levels overall (p-values<0.05). The e-diary group had Higher Metabolic Equivalents (MET) of moderate activity levels (p-value<0.05). However, the effect sizes were small. Regular adherence to the mindfulness exercises in the app was low in the group. The majority of students (94%) liked the app and found it to be acceptable. The most helpful reported meditation was the short breathing exercise observing the breath (39.5% preferred it) compared with other exercises.

Conclusion: A mindfulness app demonstrated effectiveness for stress, eating behaviors, mindfulness as well as mindful eating but the effect sizes were small. Future studies should be conducted over longer periods of time and with greater participant compliance.

 

Keynote Forum

Frank van de Goot

Symbiant Pathology Expert Centre, Netherlands

Keynote: Air toxic syndromes, myth or reality

Time : 12:00-13:00

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Frank van de Goot photo
Biography:

Frank van de Goot is a registered Anatomical Pathologist and an expert witness in the field of forensic pathology. He studied Medicine and Anatomical Pathology at the VU University Medical Center in Amsterdam, The Netherlands, and Rechtsmedizin at the Zentrum für Rechtsmedizin in Frankfurt am Main, Germany. The first seven years of his career he worked both as a Forensic Pathologist at the Dutch Forensic Institute (NFI) in The Hague, The Netherlands and as an Anatomical Pathologist at the VU University Medical Center. He now works at Symbiant Pathology Expert Centre, where he is on a mission to improve forensic and autopsy education for both medical and non-medical students.

Abstract:

Aero toxic syndrome or also toxic air syndrome is subject of debate since decades. The use of organophosphates in engine oil of modern airplanes is considered, even in very low concentrations can be toxic for the nerve system. Many auteurs claim this toxicity however many others deny the thesis. We investigated nine people employed in the aviation industry who died unexpectedly. According to these findings we cannot confirm or reject the thesis but our findings certainly support the call for methodical multidisciplinary research on the matter to prove that (parts of) the thesis a correct or to reject the statement a lay the matter finally to rest.

Keynote Forum

Atique Ahmed

Fienberg School of Medicine- Northwestern University, USA

Keynote: The role of therapeutic stress induced cellular plasticity in promoting therapeutic resistance in glioblastoma

Time : 10:00-11:00

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Atique Ahmed photo
Biography:

Atique Ahmed is currently working as the Assistant Professor of Cancer Biology and Member of the Lurie Comprehensive Cancer Center, Northwestern University, USA. He has completed his PhD in Molecular Medicine from Mayo Graduate School, USA. He has over 66 publications that have been cited over 3400 times, and his publication H-index is 34 and has been the recipient of American Cancer Society Research Scholar Grant as well as his research is funded by the National Institute of Health, USA.

Abstract:

Glioblastoma (GBM) is the most common and one of the most lethal brain tumors in adults. Previously, we have shown that anti-glioma chemotherapy Temozolomide (TMZ) initiatesplasticity in glioma cells by promoting the conversion of differentiated glioma cells to
therapy resistant Glioma Stem-Like Cells (GS-lCs). Our initial investigation indicated that the Polycomb Repressor Complex 2 (PRC2) group protein EZH2 is critical for this therapy- induced cellular plasticity. Genome-wide Chromatin Immunoprecipitation (ChIP) in parallel with DNA sequencing analyses (ChIP-seq) revealed 1449 distinct regions enriched for EZH2 binding, specifically at the promoter regions of several genes including PTPRT, CDK5R2, and SIGLEC6, which work together to activate STAT3, a master transcription factor that is key in promoting the GS-IC niche. Recent reports have also demonstrated that the oncogenic activity of EZH2 is independent of PRC2. Consequently, we investigated if the non-canonical function of EZH2 is involved in chemo resistance in GBM by performing RNA seq analysis in GBM cells treated with TMZ (+/-EZH2) inhibitor. ARL13B, a member of the ADP- ribosylation factor-like protein family responsible for cilia maintenance, was the only gene whose expression was significantly down regulated in the presence of EZH2 inhibitors (6- fold, p<0.05, FDR=0.05). In the GBM patient database, ARL13B expression negatively correlates with time to recurrence. The shRNA-mediated knockdown of ARL13B in the Patient-derived Xenograft (PDX) model of GBM significantly impaired the ability of cells to form an orthotropic tumor in three different GBM subtypes. Most importantly, knocking down ARL13B significantly sensitized PDXs to TMZ therapy. These results suggest that a novel EZH2-ARL13B axis contributes to chemo resistance in GBM by promoting cellular plasticity regulated therapeutic adaptation.

  • Psychiatry and Psychology
Location: Tokyo
Speaker
Biography:

Lynnette Lyzwinski is pursuing her PhD in Medicine at the School of Medicine at University of Queensland in the Department of Psychiatry and the Centre for Online Health. Her research interests include clinical trials and health promotions behaviors for promoting mental well-being and reducing lifestyle behavioral risk factors. She has special interests in mHealth, mindfulness and lifestyle medicine.

 

Abstract:

Background: University students are at risk of weight gain during their studies. Key factors related to weight gain in this population include unhealthy weight related behaviors due to stress. Mindfulness holds promise for weight management. However, there has not been a previous trial that has explored the effectiveness of a student-tailored mindfulness app for stress, weight related behavior’s and weight. There is limited evidence that current mindfulness apps use evidence-based mindfulness techniques. A novel app was developed that combined evidence-based mindfulness-based stress reduction and mindful eating techniques that were tailored to university students, with student relevant themes for targeting weight behavior’s, weigh and stress.

Method: A two arm Randomized Controlled Trial (RCT) of 11 weeks duration was undertaken at the University of Queensland. Students were randomized to the mindfulness app (N=45) or to a behavioral self-monitoring electronic diary (e-diary) (N=45) for diet and exercise. Analysis of covariance was used to compare differences in weight, stress, mindfulness, mindful eating, physical activity and eating behaviors between both groups.

Results: Neither the mindfulness app group nor the e-diary group lost weight nor there were no differences between groups at follow-up. The mindfulness app group had significantly lower stress levels (adherers only), lower emotional eating and uncontrolled eating as well as higher mindfulness and mindful eating levels overall (p-values<0.05). The e-diary group had Higher Metabolic Equivalents (MET) of moderate activity levels (p-value<0.05). However, the effect sizes were small. Regular adherence to the mindfulness exercises in the app was low in the group. The majority of students (94%) liked the app and found it to be acceptable. The most helpful reported meditation was the short breathing exercise observing the breath (39.5% preferred it) compared with other exercises.

Conclusion: A mindfulness app demonstrated effectiveness for stress, eating behaviors, mindfulness as well as mindful eating but the effect sizes were small. Future studies should be conducted over longer periods of time and with greater participant compliance.

 

Biography:

Ankita Gupta is Senior Resident at Post Graduate Institute of Medical Education and Research, Chandigarh, India

Abstract:

This prospective study was conducted to investigate the impact of prophylactic Granulocyte- Colony Stimulating Factor (G-CSF) on acute hematological toxicity and treatment interruptions in patients of medulloblastoma receiving Craniospinal Irradiation (CSI). Patients of medulloblastoma post-surgical excision were given CSI in a dose of 36 Gy at 1.8 Gy per fraction and concurrent vincristine along with biweekly administration of G-CSF in a dose of 15 mg/kg, followed by a Posterior Fossa (PF) boost of 18 Gy. Weekly hemogram was performed for documentation of hematological toxicity and resultant treatment interruptions were noted. The results were compared with historical controls from a retrospective analysis conducted at our institute. A total of 28 patients were included in the study. Hematological toxicity was observed in 11 (39.3%) patients, of which grade 3 and grade 2 toxicities were seen in 10 and 1 patients respectively (RTOG). All these patients suffered breaks in CSI. Of these, interruptions lasting for more than 5 days were observed only in 2 (7.6%) patients. This is well below the results from our previous analysis when patients did not receive prophylactic G-CSF during CSI and 73.1% suffered treatment breaks due to hematological toxicity. We also observed that younger age (&lt;10 years) was significantly associated with the development of hematological toxicity (p=0.028, Chi-Square), while no correlation was obtained with pre-treatment blood counts. The interim results of this study suggest that prophylactic application of G-CSF during CSI for medulloblastoma results in lower hematological toxicity and hence, less treatment interruptions. Recruitment is ongoing and whether this approach translates into improved treatment efficacy will be confirmed after the final results with longer follow-up are obtained.

Biography:

Loreto Yanez is a Congress of Neurological Surgeons Systematic Review and Evidence- Based Guidelines on the Use of Stereotactic Radiosurgery in the Treatment of Adults With Metastatic Brain Tumors. Graber, J. et al.

Abstract:

On March, 2016, the first Cyber knife M6 started Radiosurgery treatments at Fundación Arturo López Perez, in Santiago de Chile. This was the third facility in Chile with available radiosurgery in our country, the other centers have: Gamma knife (2) and LINAC based (1). Until April 2019, 309 patients have been treated, both intra and extra cranial. Intracranial cases comprehend the 51.6% of the cases, more than half of these were brain metastases. We present interesting neuro-cases to illustrate our experience. Conclusion: Extra cranial treatment indications in our experience so far are scarce, information should be reinforced so that referal is expanded. This technique allows effective and safe treatments, widely demonstrated.

Biography:

Erika Berggren is currently working as a Health Care Development Leader at the Academic Primary Health Care Centre, Stockholm County Council and affiliated with Karolinska Institute's Department of Neurobiology, Care Sciences and Society.

 

Abstract:

Primary health care professionals can find it difficult to participate in continuing education despite their need for up-to-date knowledge. Suitable models for addressing this problem are rare. Th is study aimed to evaluate a continuing educational model tailored for primary health care circumstances (ConPrim). Th e model considers the need for inter-professional education to facilitate teamwork; pedagogical theory and methods to achieve a deeper level of understanding; and content adapted to the circumstances of primary health care to help fi ll knowledge gaps and make attendance more attractive. ConPrim consists of three steps that build on each other: a web-based program, a practical exercise, and a case seminar. Th is study tested ConPrim by using it to develop and evaluate an intervention in the subject “Nutritional care of patients cared for at home.” District nurses/registered nurses and general practitioners/physicians (n=87) working with home care at 10 primary health care centers in Stockholm, Sweden, completed a post-intervention questionnaire about the model. Th e professionals found the design attractive and user-friendly and the pedagogical methods to promote inter-professional and interactive learning. They rated the time spent as acceptable for all parts except the practical exercise; found the design suitable to primary health care; and thought the intervention increased their knowledge about a subject they viewed as useful and relevant to their work. ConPrim seems well-suited for continuing inter-professional education in primary health care. Future studies could test the model in other subject areas where there is a gap between evidence-based knowledge and practice.

 

  • Research Education and case studies on Menta health
Location: Tokyo
Biography:

Young-Cho Koh is a Neurosurgeon at Konkuk University Hospital, South Korea

Abstract:

From 2009 to 2017, 215 patients with brain metastases were treated by Stereotactic Radiosurgery (SRS), among which 58 patients underwent surgery. Sixteen of them underwent surgery after SRS due to neurological deterioration, of which pathologies were classified as three groups. Group-1 was radiation necrosis (n=5), group-2 was mixed type with radiation necrosis and tumor remnant (n=2) and group-3 was tumor dominant type (n=9). We compared the surgical outcomes in respect of steroid and/or Mannitol dosage, Karnofsky performance scale and pathological subgroups. The median overall survival was 11 months (range, 2-40 months). Six, 12 and 24 months survival rates were 64.3, 42.9 and 28.6 months, respectively. Improvement of KPS was achieved in 50% of cases after surgery. The overall survival of the group-1 (26.6 months) was significantly longer than the other groups (11.5 months). Additionally the patients were able to be weaned from medications after surgery in 12 cases and dosage reduction in six cases. The time interval within three months between the SRS and surgery seemed to be related with better local control. We suggest in patients with brain metastases who had undergone SRS and radiologic and symptomatic progression, palliative resection to relieve neurologic and radiologic deterioration.
 

Biography:

Lena Lund has completed PhD in Medical Science from Karolinska Institute in 2015. She is currently working as a Head of the Lifestyle Unit at the Academic Primary Health Care Centre in Stockholm.

Abstract:

Chronic Obstructive Pulmonary Disease (COPD) is mostly caused by smoking and patients’ prognoses are related to whether or not they continue to smoke aft er diagnosis. Quitting is therefore crucial to COPD treatment, but many patients find it difficult to stop smoking. To investigate which factors infl uence quit attempts among patients with COPD, our research group interviewed smokers with COPD to identify factors associated with success in quitting. Th ese factors were used to develop the Trying to quit smoking Questionnaire (TTQ), which measures pressure-fi lled mental states, use of destructive pressure-relief strategies and ambivalent thoughts about quitting. Th is study evaluated whether the TTQ could predict smoking cessation outcomes in smokers with COPD. One hundred and nine smokers completed the TTQ at baseline and three months later. Logistic regression was used to measure the association between TTQ scores and making at least one quit attempt, reducing the intensity of smoking, and achieving abstinence. Higher total TTQ scores were signifi cantly associated with a lower probability of at least one quit attempt. In a secondary analysis, we found that patients who were ready to make a quit attempt but also experienced pressure-fi lled mental states had a lower probability of attempting to quit. However, patients who did not feel ready to quit and who simultaneously experienced pressure-fi lled mental states halved the number of cigarettes they smoked. The TTQ can identify specifi c mental processes related to success in quitting and can be useful when counselling patients with COPD who need to quit smoking.

 

Biography:

Liisa Samuelsson has completed her MSc in Medical Science at Karolinska Institute in 2017. She works as a Health Care Development Leader in the field of nutritional care, developing and providing continuing professional education for primary health care personnel in Stockholm County.

 

Abstract:

In 2011, the Stockholm County Council gave District Nurses (DNs) the right to prescribe Oral Nutritional Supplements (ONS). DNs are registered nurses who have completed an additional year of specialist education in primary care. Th e council charged the academic primary health care center with developing a course that would give DNs the knowledge they needed and the right to prescribe ONS. A group at the center used the Structure of the Observed Learning Outcome (SOLO) taxonomy to design a two-and-a-half-day course that covers identifying and analyzing older patients’ nutritional problems, planning and carrying out nursing care measures, prescribing ONS and following up and evaluating the measures. Th is questionnaire study evaluated participants’ perceived nutritional care and actual level of knowledge about nutritional care before and after the course. A total of 493 district nurses in Stockholm County participated in the course, which was given over a period of two to three months. Before and aft er the intervention, participants completed a study-specifi c questionnaire that covered their perceived nutritional care and actual level of knowledge. Th ere were signifi cant improvements in participants work with nutrition care and in their knowledge of all subject areas covered aft er the course (p=0.000-0.014). However, all participants did not fully achieve all learning objectives. DNs’ improvements as a result of the intervention lay the foundation for good nutritional care for older patients in primary care. Th e results have been used to improve the course, and an assessment of the revised course is ongoing.