Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 30th International Conference on Psychiatry and Mental Health Tokyo, Japan.

Day 1 :

Keynote Forum

Nigila Ravichandran

Adjunct Assistant Professor & Consultant Institute of Mental Health, Singapore

Keynote: Does Educational Level Influence Sustained Employment in Patients with Schizophrenia?

Time : 11:00-11:45

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Nigila Ravichandran  photo
Biography:

Dr Nigila Ravichandran MBBS (India), Master of Medicine (Psychiatry) (NUS Singapore), Dip Hypnotherapy (LCCH) Adjunct Assistant Professor, Lee Kong Chian School of Medicine (Singapore) Senior Lecturer, Yong Loo Lin School of Medicine (Singapore) Consultant, Psychiatrist, Institute of Mental Health (Singapore) 17 years of experience working in the field of mental health, in areas of clinical psychiatry, academic teaching and research Passion for community causes, speaker at Community events and forums, television and health fairs on mental wellness and mental health conditions Board member of Club2Care, charity organization, geared towards creating awareness about mental health, training and counselling community partners and building a mentally healthy society

Abstract:

Background

Schizophrenia is a chronic mental illness causing significant socio-occupational impairment. Although occupational opportunities usually correspond with educational qualifications, research shows that several factors influence employment among mentally ill (1). Higher education correlates with better outcome with rehabilitative measures like cognitive training (2).

An observational study was conducted at the Institute of Mental Health (IMH), the tertiary mental healthcare and rehabilitation centre at Singapore, to identify major variables associated with employment among patients with Schizophrenia.

In Singapore, all residents receive at least primary level education.

Objectives

To explore whether educational status determines employability and job sustainability in persons with schizophrenia.

Methods

Residents of Singapore with DSM-IV diagnosis of Schizophrenia attending IMH clinics were included for study. Relevant data was collected from 120 consenting participants.

Results

Of the 120 participants, 49.2% had attained secondary education and 18.3% employed; 31.7% had university education and 15% were employed. In total, 38.3% were working at time of study and 60.8% in the past.

87.5% (43% secondary and 30% university educated respectively) participants had rehabilitation potential as expressed by self-interest and past employment.

Conclusions

Educational level only facilitates initial job-seeking and does not ensure long-term employment; but it improves potential for rehabilitation, which in turn enhances job sustainability in mentally unwell persons.

 

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Lyzwinski Lynnette Nathalie photo
Biography:

Lynnette Lyzwinski is completed her PhD in Medicine at the school of Medicine at UQ in the Department of Psychiatry and the Centre for Online Health. Her research interests include clinical trials and health promotions behaviors for promoting mental wellbeing and reducing lifestyle behavioral risk factors. She has special interests in mHealth, mindfulness, and lifestyle medicine.

 

Abstract:

Background: University students are at risk of weight gain during their studies. Key factors related to weight gain in this population include unhealthy weight related behaviors due to stress. Mindfulness holds promise for weight management. However, there has not been a previous trial that has explored the effectiveness of a student-tailored mindfulness app for stress, weight related behavior’s and weight. There is limited evidence that current mindfulness apps use evidence-based mindfulness techniques. A novel app was developed that combined evidence-based mindfulness-based stress reduction and mindful eating techniques that were tailored to university students, with student relevant themes for targeting weight behavior’s, weigh and stress.

Method: A two arm Randomized Controlled Trial (RCT) of 11 weeks duration was undertaken at the University of Queensland. Students were randomized to the mindfulness app (N=45) or to a behavioral self-monitoring electronic diary (e-diary) (N=45) for diet and exercise. Analysis of covariance was used to compare differences in weight, stress, mindfulness, mindful eating, physical activity and eating behaviors between both groups.

Results: Neither the mindfulness app group nor the e-diary group lost weight nor there were no differences between groups at follow-up. The mindfulness app group had significantly lower stress levels (adherers only), lower emotional eating and uncontrolled eating as well as higher mindfulness and mindful eating levels overall (p-values<0.05). The e-diary group had Higher Metabolic Equivalents (MET) of moderate activity levels (p-value<0.05). However, the effect sizes were small. Regular adherence to the mindfulness exercises in the app was low in the group. The majority of students (94%) liked the app and found it to be acceptable. The most helpful reported meditation was the short breathing exercise observing the breath (39.5% preferred it) compared with other exercises.

Conclusion: A mindfulness app demonstrated effectiveness for stress, eating behaviors, mindfulness as well as mindful eating but the effect sizes were small. Future studies should be conducted over longer periods of time and with greater participant compliance.

 

Keynote Forum

Frank van de Goot

Symbiant Pathology Expert Centre, Netherlands

Keynote: Air toxic syndromes, myth or reality

Time : 12:00-13:00

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Frank van de Goot photo
Biography:

Frank van de Goot is a registered Anatomical Pathologist and an expert witness in the field of forensic pathology. He studied Medicine and Anatomical Pathology at the VU University Medical Center in Amsterdam, The Netherlands, and Rechtsmedizin at the Zentrum für Rechtsmedizin in Frankfurt am Main, Germany. The first seven years of his career he worked both as a Forensic Pathologist at the Dutch Forensic Institute (NFI) in The Hague, The Netherlands and as an Anatomical Pathologist at the VU University Medical Center. He now works at Symbiant Pathology Expert Centre, where he is on a mission to improve forensic and autopsy education for both medical and non-medical students.

Abstract:

Aero toxic syndrome or also toxic air syndrome is subject of debate since decades. The use of organophosphates in engine oil of modern airplanes is considered, even in very low concentrations can be toxic for the nerve system. Many auteurs claim this toxicity however many others deny the thesis. We investigated nine people employed in the aviation industry who died unexpectedly. According to these findings we cannot confirm or reject the thesis but our findings certainly support the call for methodical multidisciplinary research on the matter to prove that (parts of) the thesis a correct or to reject the statement a lay the matter finally to rest.

Keynote Forum

Atique Ahmed

Fienberg School of Medicine- Northwestern University, USA

Keynote: The role of therapeutic stress induced cellular plasticity in promoting therapeutic resistance in glioblastoma

Time : 10:00-11:00

Conference Series Psychiatry Mentalhealth 2019 International Conference Keynote Speaker Atique Ahmed photo
Biography:

Atique Ahmed is currently working as the Assistant Professor of Cancer Biology and Member of the Lurie Comprehensive Cancer Center, Northwestern University, USA. He has completed his PhD in Molecular Medicine from Mayo Graduate School, USA. He has over 66 publications that have been cited over 3400 times, and his publication H-index is 34 and has been the recipient of American Cancer Society Research Scholar Grant as well as his research is funded by the National Institute of Health, USA.

Abstract:

Glioblastoma (GBM) is the most common and one of the most lethal brain tumors in adults. Previously, we have shown that anti-glioma chemotherapy Temozolomide (TMZ) initiatesplasticity in glioma cells by promoting the conversion of differentiated glioma cells to
therapy resistant Glioma Stem-Like Cells (GS-lCs). Our initial investigation indicated that the Polycomb Repressor Complex 2 (PRC2) group protein EZH2 is critical for this therapy- induced cellular plasticity. Genome-wide Chromatin Immunoprecipitation (ChIP) in parallel with DNA sequencing analyses (ChIP-seq) revealed 1449 distinct regions enriched for EZH2 binding, specifically at the promoter regions of several genes including PTPRT, CDK5R2, and SIGLEC6, which work together to activate STAT3, a master transcription factor that is key in promoting the GS-IC niche. Recent reports have also demonstrated that the oncogenic activity of EZH2 is independent of PRC2. Consequently, we investigated if the non-canonical function of EZH2 is involved in chemo resistance in GBM by performing RNA seq analysis in GBM cells treated with TMZ (+/-EZH2) inhibitor. ARL13B, a member of the ADP- ribosylation factor-like protein family responsible for cilia maintenance, was the only gene whose expression was significantly down regulated in the presence of EZH2 inhibitors (6- fold, p<0.05, FDR=0.05). In the GBM patient database, ARL13B expression negatively correlates with time to recurrence. The shRNA-mediated knockdown of ARL13B in the Patient-derived Xenograft (PDX) model of GBM significantly impaired the ability of cells to form an orthotropic tumor in three different GBM subtypes. Most importantly, knocking down ARL13B significantly sensitized PDXs to TMZ therapy. These results suggest that a novel EZH2-ARL13B axis contributes to chemo resistance in GBM by promoting cellular plasticity regulated therapeutic adaptation.